MOTS-c, 10mg

Product Category

Mitochondrial-Derived Peptides (MDPs), AMPK Activators & Metabolic Regulators

Action on the Human Body

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a naturally occurring 16-amino acid peptide encoded within the mitochondrial genome. It functions as an endocrine signaling factor that translocates directly to the nucleus during metabolic stress to alter gene expression, acting primarily via the activation of the AMP-activated protein kinase (AMPK) pathway. By turning on AMPK, MOTS-c accelerates glucose uptake into skeletal muscle independent of insulin, upregulates fatty acid oxidation, suppresses the creation of new fat cells (adipogenesis), and promotes the browning of white adipose tissue. This action counters diet-induced insulin resistance, lowers systemic inflammation, and stimulates mitochondrial biogenesis to elevate cellular aerobic capacity and cellular energy production.

What to Expect if Consumed

Users report a substantial leap in exercise performance and cardiorespiratory endurance, improved weight loss progress, steadier blood sugar levels throughout the day, and reduced overall muscle fatigue.

Possible Therapy Combinations

Pairs perfectly with 5-Amino-1MQ to create an elite, highly synergistic metabolic fat oxidation and cellular power protocol, or combined with NAD+ to maximize total mitochondrial output.

Molecular Formula & Chemical Composition

Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Leu-Pro-Arg-Lys-Cys-Arg. Molecular Formula: C101H152N28O22S2. Purity: >99% Pure Lyophilized Mass via strict HPLC verification.

WARNING: This peptide compound must be handled and utilized exclusively under very high, correct professional and qualified medical supervision. Misuse can lead to unintended biological variations.

Scientific References

1. Lee, C., et al. (2015). ‘The mitochondrial-derived peptide MOTS-c regulates metabolic homeostasis and prevents insulin resistance.’ Cell Metabolism.
2. Reynolds, J. C., et al. (2021). ‘Mitochondrial-derived peptide MOTS-c promotes physical performance and rejuvenates skeletal muscle metabolism in aging models.’ Nature Communications.