Product Category
Senolytic Peptides & Advanced Cellular Clearance Factors
Action on the Human Body
FoxO4-DRI (Forkhead box O4 D-Retro-Inverso) is a synthetic 49-amino acid peptide designed to selectively disrupt the intracellular interaction between the transcription factor FOXO4 and the p53 tumor suppressor protein inside senescent (zombie) cells. In damaged or aging cells, senescent states are sustained because FOXO4 sequesters p53 inside the cell nucleus, preventing it from initiating necessary cell clearance pathways (apoptosis). FoxO4-DRI acts as a competitive antagonist; by blocking this interaction, it permits p53 to translocate freely to the mitochondria, which rapidly triggers targeted apoptosis exclusively within senescent lines. This selective clearance clears toxic Senescence-Associated Secretory Phenotype (SASP) factors from tissues, clearing the way for healthy stem cells to replicate and rebuild functional systemic organs.
What to Expect if Consumed
Users report a massive reduction in general physical soreness, visible skin texture improvements, rapid muscle tissue recovery under training loads, and a profound renewal of baseline systemic energy fields.
Possible Therapy Combinations
Pairs phenomenally well with Epitalon (50mg) to length telomeres in newly replicating cells after the senescent cells have been cleared, or stacked with GHK-Cu for high-performance skin and tissue remodeling.
Molecular Formula & Chemical Composition
Sequence: D-Retro-Inverso modification of the native human FOXO4-p53 binding domain. Molecular Formula: C234H376N72O73S4. Purity: >98% via precise HPLC and MS characterization.
WARNING: This peptide compound must be handled and utilized exclusively under very high, correct professional and qualified medical supervision. Misuse can lead to unintended biological variations.
Scientific References
1. Baar, M. P., et al. (2017). ‘Targeted apoptosis of senescent cells by a FOXO4-p53 interfering peptide restores tissue homeostasis in senescent mice.’ Cell.
2. de Keizer, P. L. (2018). ‘The progress of therapeutic senolytics: FoxO4-DRI and the selective elimination of senescent cells.’ Trends in Molecule Medicine.
Why choose our FoxO4-DRI, 10mg?
- Guaranteed 99%+ Purity: Synthesized specifically for rigorous laboratory and analytical research.
- Strict Quality Control: Verified via HPLC and MS testing to ensure precise molecular concentration.
- Secure & Stable Shipping: Packaged carefully to maintain compound stability during transit.
Note: This product is sold exclusively for laboratory research purposes only. It is not intended for human or veterinary use.
