LL-37, 5mg

Product Category

Antimicrobial Peptides (AMPs), Biofilm Disruptors & Immunomodulators

Action on the Human Body

LL-37 is a 37-amino acid, amphipathic alpha-helical peptide derived from the C-terminal end of the human cathelicidin antimicrobial protein (hCAP18). It functions as a broad-spectrum host defense peptide that destabilizes the cellular membranes of Gram-positive and Gram-negative bacteria, fungi, and enveloped viruses via electrostatic binding and toroidal pore formation. Crucially, LL-37 penetrates and disrupts complex bacterial biofilms that hide resistant chronic infections. Beyond its direct antimicrobial profile, it acts as an effective immunomodulator by binding formyl peptide receptor-like 1 (FPRL1) to recruit necessary immune cells, neutralize pro-inflammatory lipopolysaccharides (LPS), and trigger controlled angiogenesis to rapidly heal infected wounds.

What to Expect if Consumed

Users note a clear reduction in persistent localized or systemic infections, accelerated clearing of chronic skin or gut wounds, a drop in biofilm-related flare-ups, and improved immune response stability.

Possible Therapy Combinations

Pairs exceptionally well with BPC-157 to clear underlying gut pathogens while simultaneously closing loose tissue structures along damaged intestinal walls, or combined with KPV to manage chronic inflammatory skin conditions.

Molecular Formula & Chemical Composition

Sequence: Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser. Molecular Formula: C205H340N60O53. Purity: >98.5% via precise HPLC and MS characterization.

WARNING: This peptide compound must be handled and utilized exclusively under very high, correct professional and qualified medical supervision. Misuse can lead to unintended biological variations.

Scientific References

1. Bowdish, D. M., et al. (2005). ‘The human cathelicidin LL-37 is a multifunctional modulator of innate immune responses.’ Journal of Leukocyte Biology.
2. Overhage, J., et al. (2008). ‘Human host defense peptide LL-37 prevents bacterial biofilm formation.’ Infection and Immunity.